Keys to this one:
1) Go to CJ early and often. Yeah, he was awful finding the holes last match-up, but he only got nine carries. Give him the ball and eventually he'll break one. I mean, Chris Brown and Steve Slaton had decent days against the Colts defense and Johnson is miles better than them.
2) Convert in the red zone. If you look at the stats, the Titans dominated last week according to yardage. Why only 20 points? Missed opportunities which forced field goals from Rob Bironas. And at the end of the first half, Vince tried to make something happen and ended up running out the clock while the Titans still had a timeout. Make the red zone trips count with touchdowns instead of field goals, and make Manning play from behind.
3) Get pressure on that 6'5", rocket, laser armed quarterback. The defensive line has been disrupting more plays lately and they will need to get into Manning's face a few times to help out the bad (but better than last match-up) secondary. Cortland Finnegan is thankfully healthy for this one, and as much as I hate Nick Harper, he is still an improvement over the rookie corners Jason McCourty and Ryan Mouton.
Like I said before, this game right here is Tennessee's season. I think it's going to be a great one, and I have the Titans winning by 3, but I wouldn't be surprised to see the Colts win by the same margin.