Too many movies, but I'm a huge pussy when it comes to getting bromotional. "Up" had me in tears in the first five minutes when I saw it in theaters. God damn that opening sequince is sad.
As for TV shows, Friday Night Lights has never made me crym but I get choked up routinely. It gets a little dusty for me all the time when watching that show. (Any time Coach Taylor gives a speech, when Riggins went to jail, Saracen in the shower, Saracen's dad, etc.)
The Wire has gotten me choked up, or just ruined my day on multiple occasions. Usually when major characters died, or with what happens with the kids in season 4.