Haven't played the game long enough to get a real good wish list built up, but just off the top of my head:
-I like the new animations in game with the refs arguing, and the chain gang, and the QB talking on the phone...but we need more of these. Excellent idea, now give me variety. Give me some cheerleaders, give me the defensive coord. with a white board going over plays with his group in a huddle, give me a huddle on the sideline with players squeezing water bottles during timeouts, give me guys sitting on the bench and talking to each other, give me a kicker warming up his leg by kicking into the net.
-The user pass rush sucks. Fix it. Sliders should be in place to tweak a game to each player's liking, not fix the whole damn thing.
-When negotiating a player's contract, I'd like to see more CPU reaction similar to Head Coach. Throw a number out for me...just saying "Nope, need more money" is no good. However, DO NOT implement the Head Coach thing of having a select number of packages to offer, or a time limit before the player walks. I hated that.
-I've always been a big fan of a more fluid offseason that would use more of a Head Coach style of a day-by-day process instead of just set tasks. I'd like to be able to not re-sign some of my players right away, and maybe let them test the free agent market. I think it'd be cool to have some retirements right away, and maybe get a notification of a guy who is contemplating retirement. Then maybe you could talk to him. Perhaps a trade (after all, there's no value in a guy who leaves the game, might as well get something out of him) or a new contract could get him to stick around. Bringing in free agents for a tour of the facilities in order to boost interest (similar to the NCAA approach of recruiting) would be nice.