I'm starting to wonder if AC3 will be Desmond's story with very little animus (though, I really was hoping for industrial era London).
I'm not sure how far through I am through the main story, though reading the actual history, it's good that they're sticking to most of it.
I have all of the Borgia towers down, all 10 assassins going, 4 of which have been accepted into the brotherhood. I have over 80% of Rome rebuilt, with one district being at 98% (I think I just have to buy the Palazzo Senatoro).
At some point, I have to find the other glyphs. I only have 2.
In the plotlines: