I'm disappointed that nobody has mentioned Supernatural. Yes, it's on the WB. Yes, it has 2 hunky dudes as the leads.
However, this has the tightest story of pretty much anything that's been on TV for the last 4-5 years. If you do choose to watch, season 1 starts pretty slow (monster of the week), season 2 is really good, season 3 is great...and seasons 4 and 5 are pretty much the best 2 season run of any show I've seen in a very, very long time.
Do yourselves a favor, check it out. The show is legitimately entertaining, and pretty damned funny at times. 7 seasons and going strong.